Update-Manager window frequently pop-up when I’m operating on my Ubuntu machine.

It’s very annoying and follow is what I did in my Ubuntu Karmic machine to disable this annoying pop-up window.

Step1: Go to System->Administration->Software Sources->Updates tab,un-tick all check-boxes.
update-manager

Step2: Go to System->Preferences->Startup Applications->Un-tick “Update Notifier”
update-manager1

Hope this help,and you can manually run update-manager from System->Administration->Update Manager to update your system.